desipramine
Jan B. I have had migraines for 30 years on and off. I am now taking desipramine 75mg daily and I have been for 5 years. It has lowered the severity of the headache and cut back on the number. I take it at night because it does make me a little sleepy. It also makes your mouth dry which tends to make you drink or suck on hard candy. I hope this has helped. Sue